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Medically reviewed by Alan Carter, Pharm. Getting behind the wheel of a car or operating machinery after drinking lean increases the likelihood of accidents.

As a depressant, alcohol can cause sedation and even euphoria. Once the buzz from the drink wears off, however, you may feel very sleepy and possibly depressed. Alcohol also essentially amplifies the effects of the other drugs. This is concerning because the body can and will react in unpredictable ways. In other cases, the body may simply shut down. For example, DJ Screw died in due to a codeine-promethazine-alcohol overdose. Take care of your lungs: Avoid smoking or vaping any substance.

National Institutes of Health. What Is Lean? High doses of codeine can lead to a deadly overdose , by stopping the heart and lungs from working completely.

Mixing codeine with alcohol or other drugs significantly increases that risk. Extended drinking of lean, especially in high doses, may cause more intense withdrawals such as abdominal cramps, nausea, dilated pupils, diarrhea, and vomiting. At times, these symptoms can become so uncomfortable that people resort back to drinking Lean.

Unfortunately, this only leads to an endless cycle of abuse that may require inpatient rehab before individuals achieve long-lasting recovery. Most people who begin drinking Lean think that cough syrup makes it safe.

However, Purple Drank can lead to disastrous health problems that could also lead to death. Side effects gradually worsen as the person drinks more of this highly addictive concoction. Even first-time users may experience unpleasant side effects such as nausea, blurred vision, dizziness, and memory issues.

Regular use causes a person to suffer from constipation, tooth decay, weight gain, and urinary tract infections. Long-term use, particularly when combined with other drugs, can lead to life-threatening effects. Reports show that risking death increases when Lean is combined with alcohol or sedative drugs.